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Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy.

作者信息

Diasio R B, Lu Z

出版信息

J Clin Oncol. 1994 Nov;12(11):2239-42. doi: 10.1200/JCO.1994.12.11.2239.

DOI:10.1200/JCO.1994.12.11.2239
PMID:7964937
Abstract
摘要

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Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy.二氢嘧啶脱氢酶活性与氟尿嘧啶化疗
J Clin Oncol. 1994 Nov;12(11):2239-42. doi: 10.1200/JCO.1994.12.11.2239.
2
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4
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Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy.
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6
Estimation of dihydropyrimidine dehydrogenase activity: does it have a role in cancer therapy?二氢嘧啶脱氢酶活性的评估：其在癌症治疗中起作用吗？
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5-fluorouracil and dihydropyrimidine dehydrogenase.5-氟尿嘧啶与二氢嘧啶脱氢酶
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[5-fluorouracil and dihydropyrimidine dehydrogenase].[5-氟尿嘧啶与二氢嘧啶脱氢酶]
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Gender differences in the dihydropyrimidine dehydrogenase expression may contribute to higher toxicity in women treated with 5-fluorouracil therapy.二氢嘧啶脱氢酶表达的性别差异可能导致接受5-氟尿嘧啶治疗的女性毒性更高。
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