Reddy A Babul, Manjula B, Jayaramudu T, Sadiku E R, Anand Babu P, Periyar Selvam S
1Department of Chemical, Metallurgical and Materials Engineering, Tshwane University of Technology, CSIR Campus, Building 14D, Lynwood Ridge, Private Bag X025, Pretoria, 0040 South Africa.
2Department of Food Process Engineering, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu 603203 India.
Nanomicro Lett. 2016;8(3):260-269. doi: 10.1007/s40820-016-0086-4. Epub 2016 Mar 16.
In the present study, chitosan and polyvinyl alcohol (PVA) were blended with different concentrations of sodium montmorillonite (NaMMT) clay solution by a solvent casting method. X-ray diffraction and transition electron microscope results show that the film properties are related to the co-existence of NaMMT intercalation/exfoliation in the blend and the interaction between chitosan-PVA and NaMMT. 5-Fluorouracil (5-FU) was loaded with chitosan-PVA/NaMMT nanocomposite films for in vitro drug delivery study. The antimicrobial activity of the chitosan-PVA/NaMMT films showed significant effect against (-) and (-), whereas 5-FU encapsulated chitosan-PVA/NaMMT bio-nanocomposite films did not show any inhibition against bacteria. Our results indicate that combination of a flexible and soft polymeric material with high drug loading ability of a hard inorganic porous material can produce improved control over degradation and drug release. It will be an economically viable method for preparation of advanced drug delivery vehicles and biodegradable implants or scaffolds.
在本研究中，壳聚糖和聚乙烯醇（PVA）通过溶液浇铸法与不同浓度的钠基蒙脱石（NaMMT）粘土溶液混合。X射线衍射和透射电子显微镜结果表明，薄膜性能与共混物中NaMMT插层/剥离的共存以及壳聚糖 - PVA与NaMMT之间的相互作用有关。将5-氟尿嘧啶（5-FU）负载于壳聚糖 - PVA/NaMMT纳米复合薄膜中进行体外药物递送研究。壳聚糖 - PVA/NaMMT薄膜对（-）和（-）显示出显著的抗菌活性，而负载5-FU的壳聚糖 - PVA/NaMMT生物纳米复合薄膜对细菌没有显示出任何抑制作用。我们的结果表明柔性软质聚合物材料与硬质无机多孔材料的高载药能力相结合，可以更好地控制降解和药物释放。这将是制备先进药物递送载体和可生物降解植入物或支架的一种经济可行的方法。
