Murphy P A, Jones E
Columbia University School of Nursing, New York, NY 10032.
J Nurse Midwifery. 1994 Jul-Aug;39(4):214-20. doi: 10.1016/0091-2182(94)90027-2.
Metronidazole is the recommended treatment for trichomoniasis and bacterial vaginosis in nonpregnant women. Reluctance to use this drug in pregnancy is related to concerns about possible adverse effects on the fetus. However, recent literature suggests associations between these infections during pregnancy and risk of preterm delivery; if such associations are causal and preterm birth is shown to be prevented by effective treatment, the risk-benefit equation may be altered. This article reviews the literature on the carcinogenic and teratogenic potential of metronidazole and discusses the evidence that associates trichomoniasis and bacterial vaginosis with perinatal outcomes. Current practice recommendations are summarized.
甲硝唑是治疗非孕妇滴虫病和细菌性阴道病的推荐药物。孕期不愿使用该药与担心对胎儿可能产生不良反应有关。然而，近期文献表明孕期这些感染与早产风险之间存在关联；如果这种关联是因果关系，且有效治疗能预防早产，那么风险效益平衡可能会改变。本文综述了关于甲硝唑致癌和致畸潜力的文献，并讨论了将滴虫病和细菌性阴道病与围产期结局相关联的证据。总结了当前的实践建议。
