硬脂酸在大鼠体内的淋巴转运及其对胆固醇转运的影响。

Lymphatic transport of stearic acid and its effect on cholesterol transport in rats.

作者信息

Ikeda I, Imasato Y, Nakayama M, Imaizumi K, Sugano M

机构信息

Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 1994 Jun;40(3):275-82. doi: 10.3177/jnsv.40.275.

DOI:10.3177/jnsv.40.275

PMID:7965216

Abstract

Lymphatic transport of stearic acid, given as completely hydrogenated rapeseed oil (R10), 9 to 1 (R9) and 5 to 5 (R5) mixtures of R10, and soybean oil and completely hydrogenated tallow (T) was examined in the rat cannulated thoracic duct. R10, R9, R5, and T contained 91.4, 81.5, 46.5, and 63.6% stearic acid, respectively. A large portion of the remaining fatty acids in T was palmitic acid (31%). These fats were emulsified with bile salt and albumin, and administered via a stomach tube. Lymphatic recovery of stearic acid at 24 h was lowest in R10 and highest in R5, and intermediate in R9 and T. Recovery of oleic and linoleic acids in rats given R5 was almost complete and significantly higher than that of stearic acid. When T was given, the 24 h recovery of stearic acid was significantly lower than that of palmitic acid. A highly inverse correlation between the recovery and the content of stearic acid in administered fats was observed in R10, R9, and R5. Lymphatic recovery of cholesterol was almost parallel with that of stearic acid. Although the content of stearic acid in T was lower than that in R9, the recovery of stearic acid and cholesterol was almost similar. The results indicate that the rate of lymphatic recovery of stearic acid is affected by the quantity and quality of coexisting fatty acids.

摘要

在大鼠胸导管插管实验中，研究了以完全氢化菜籽油（R10）、R10与R9按9比1（R9）和R10与R5按5比5（R5）混合的油、大豆油以及完全氢化牛油（T）形式给予的硬脂酸的淋巴转运情况。R10、R9、R5和T中硬脂酸的含量分别为91.4%、81.5%、46.5%和63.6%。T中其余脂肪酸的很大一部分是棕榈酸（31%）。这些脂肪用胆汁盐和白蛋白乳化后，通过胃管给药。24小时时，硬脂酸的淋巴回收率在R10中最低，在R5中最高，在R9和T中居中。给予R5的大鼠中油酸和亚油酸的回收率几乎是完全的，且显著高于硬脂酸的回收率。给予T时，硬脂酸的24小时回收率显著低于棕榈酸的回收率。在R10、R9和R5中，观察到回收率与给药脂肪中硬脂酸含量之间存在高度负相关。胆固醇的淋巴回收率与硬脂酸的回收率几乎平行。尽管T中硬脂酸的含量低于R9中的含量，但硬脂酸和胆固醇的回收率几乎相似。结果表明，硬脂酸的淋巴回收速率受共存脂肪酸的数量和质量的影响。