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扁桃体切除术改善掌跖脓疱病皮肤损害的疗效——对札幌医科大学耳鼻喉科289例患者的评估

[Efficacy of tonsillectomy for improving skin lesions of Pustulosis palmaris et plantaris--evaluation of 289 cases at the Department of Otolaryngology of Sapporo Medical University].

作者信息

Tsubota H, Kataura A, Kukuminato Y, Hamamoto M, Ohguro S, Shido F, Takezawa H, Shintani T, Hirao M, Saitoh H

机构信息

Department of Otolaryngology, Sapporo Medical University, School of Medicine.

出版信息

Nihon Jibiinkoka Gakkai Kaiho. 1994 Sep;97(9):1621-30. doi: 10.3950/jibiinkoka.97.1621.

DOI:10.3950/jibiinkoka.97.1621
PMID:7965376
Abstract

In recent years, Pustulosis palmaris et plantaris (PPP) has been described as one of the representative second lesions of focal tonsillitis in Japan. We selected 289 cases of PPP, treated with bilateral tonsillectomy at our department over the past 12 years for this clinical evaluation. In 211 of those 289 tonsillectomy cases, follow-up was done for more than 3 months after operation. Prior to tonsillectomy, 196 cases suffered from PPP only, 90 cases had the complication of osteo-arthral lesions such as sterno-costa-clavicular hyperosteosis (SCCH), rheumatoid arthritis, and soon, whereas only 3 cases showed simultaneous lesions of Psoriasis vulgaris. The efficacy of tonsillectomy for improving the skin lesions was classified into 6 grades, mainly based upon individual evaluation by each patient as follows; disappeared, remarkably improved, improved, slightly improved, unchanged, and worsened. According to our 211 cases, post tonsillectomy improvement of skin lesions was very obvious, with disappearance occurring in 54.3% of cases and remarkable improvement in 21.4%. Age of onset and the duration from onset to tonsillectomy showed no association with effectiveness. However, the shorter the duration from onset to tonsillectomy, the fewer days were required for improvement of the skin lesions. The rate of improvement of PPP rose in conjunction with the number of days after tonsillectomy. We conclude that it requires 12 months, at minimum, to determine the efficacy of tonsillectomy as a treatment for PPP.

摘要

近年来,掌跖脓疱病(PPP)在日本被描述为局灶性扁桃体炎的代表性继发性病变之一。我们选取了289例PPP患者,在过去12年里于我科接受双侧扁桃体切除术以进行此项临床评估。在这289例扁桃体切除术中,211例术后随访超过3个月。扁桃体切除术前,196例仅患有PPP,90例伴有骨关节病变并发症,如胸锁关节骨质增生(SCCH)、类风湿关节炎等,而仅有3例同时患有寻常型银屑病。扁桃体切除术改善皮肤病变的疗效分为6个等级,主要依据每位患者的个体评估如下:消失、显著改善、改善、略有改善、无变化和恶化。根据我们的211例病例,扁桃体切除术后皮肤病变的改善非常明显,54.3%的病例皮肤病变消失,21.4%显著改善。发病年龄以及从发病到扁桃体切除术的持续时间与疗效无关。然而,从发病到扁桃体切除术的持续时间越短,皮肤病变改善所需天数越少。PPP的改善率随扁桃体切除术后天数的增加而上升。我们得出结论,至少需要12个月才能确定扁桃体切除术作为PPP治疗方法的疗效。

相似文献

1
[Efficacy of tonsillectomy for improving skin lesions of Pustulosis palmaris et plantaris--evaluation of 289 cases at the Department of Otolaryngology of Sapporo Medical University].扁桃体切除术改善掌跖脓疱病皮肤损害的疗效——对札幌医科大学耳鼻喉科289例患者的评估
Nihon Jibiinkoka Gakkai Kaiho. 1994 Sep;97(9):1621-30. doi: 10.3950/jibiinkoka.97.1621.
2
Clinical analyses of focus tonsil and related diseases in Japan.日本扁桃体病灶及相关疾病的临床分析。
Acta Otolaryngol Suppl. 1996;523:161-4.
3
Treatment outcome and prognostic factors of tonsillectomy for palmoplantar pustulosis and pustulotic arthro-osteitis: A retrospective subjective and objective quantitative analysis of 138 patients.扁桃体切除术治疗掌跖脓疱病和脓疱性关节炎的疗效和预后因素:138 例患者回顾性主观和客观定量分析。
J Dermatol. 2018 Jul;45(7):812-823. doi: 10.1111/1346-8138.14348. Epub 2018 May 6.
4
Evaluation of tonsillectomy as a treatment for pustulosis palmaris et plantaris.扁桃体切除术治疗掌跖脓疱病的评估
J Dermatol. 1977 Oct;4(5):163-72. doi: 10.1111/j.1346-8138.1977.tb01033.x.
5
[Tonsillectomy and osteoarthritic disease].
Nihon Jibiinkoka Gakkai Kaiho. 1994 Sep;97(9):1601-7. doi: 10.3950/jibiinkoka.97.1601.
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Investigation of the local provocation test to PPP and IgA nephritis.对紫癜性肾炎和IgA肾病的局部激发试验的研究。
Acta Otolaryngol Suppl. 1996;523:178-81.
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Histological features of palatine tonsils in pustulosis palmaris et plantaris: a morphometric study.掌跖脓疱病中腭扁桃体的组织学特征:一项形态计量学研究。
Pathol Int. 1994 Mar;44(3):186-93. doi: 10.1111/j.1440-1827.1994.tb02591.x.
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Possible involvement of T cell co-stimulation in pustulosis palmaris et plantaris via the induction of inducible co-stimulator in chronic focal infections.通过慢性局灶性感染中诱导性共刺激分子的诱导,T细胞共刺激可能参与掌跖脓疱病。
J Dermatol Sci. 2008 Jun;50(3):197-207. doi: 10.1016/j.jdermsci.2007.12.010. Epub 2008 Mar 4.
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Increase of activated T-cells and up-regulation of Smad7 without elevation of TGF-beta expression in tonsils from patients with pustulosis palmaris et plantaris.掌跖脓疱病患者扁桃体中活化T细胞增加,Smad7上调,而TGF-β表达未升高。
Clin Immunol. 2005 May;115(2):192-9. doi: 10.1016/j.clim.2005.01.001.
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Pre-operative diagnosis for dermatoses due to tonsillar focal infections: recent views.扁桃体局灶性感染所致皮肤病的术前诊断:近期观点
Auris Nasus Larynx. 1989;16 Suppl 1:S59-64. doi: 10.1016/s0385-8146(89)80031-8.

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