Lipponen P K, Eskelinen M J
Department of Pathology, University of Kuopio, Finland.
J Pathol. 1994 Aug;173(4):327-32. doi: 10.1002/path.1711730407.
A series of 201 bladder cancer biopsy specimens was analysed immunohistochemically for the expression of pS2 protein. Altogether, 61 per cent of the tumours were pS2-negative; in 16 per cent less than 1 per cent and in 23 per cent of cases more than 1 per cent of cells were pS2-positive. Normal transitional epithelium was negative for pS2. The fraction of positive cells was higher in poorly differentiated non-papillary tumours and in invasive tumours with pelvic lymph-node (P = 0.05) and distant metastasis (P = 0.10). pS2 expression was not related to sex, while patients aged 60-70 years had low fractions of pS2-positive cells (P = 0.03). DNA ploidy, S-phase fraction, mitotic index, morphometric nuclear features, and expression of c-erbB-2, p53, and epidermal growth factor receptor were independent of expression of pS2. Tumours expressing pS2 in over 10 per cent of cells had a lower survival probability (P = 0.0486). The results show that pS2 is expressed in 40 per cent of transitional cell bladder tumours, but that this marker has no clinical significance over established prognostic factors.
对201份膀胱癌活检标本进行了免疫组织化学分析，以检测pS2蛋白的表达。总体而言，61%的肿瘤为pS2阴性；16%的病例中pS2阳性细胞少于1%，23%的病例中pS2阳性细胞超过1%。正常移行上皮pS2呈阴性。低分化非乳头状肿瘤以及伴有盆腔淋巴结转移（P = 0.05）和远处转移（P = 0.10）的浸润性肿瘤中，阳性细胞比例更高。pS2表达与性别无关，而60 - 70岁患者的pS2阳性细胞比例较低（P = 0.03）。DNA倍体、S期分数、有丝分裂指数、形态计量学核特征以及c-erbB-2、p53和表皮生长因子受体的表达与pS2表达无关。pS2阳性细胞超过10%的肿瘤生存概率较低（P = 0.0486）。结果表明，40%的移行细胞膀胱癌表达pS2，但该标志物相对于既定的预后因素并无临床意义。
