Müller W, Borchard F
Department of Pathology, University of Düsseldorf, Germany.
J Pathol. 1993 Dec;171(4):263-9. doi: 10.1002/path.1711710406.
The presence of pS2 protein (pS2) was studied in a total of 120 consecutive patients with gastric carcinomas. This immunohistochemical study found pS2 expression in 48 per cent (n = 58) of carcinomas. pS2 expression was also detected in normal gastric mucosa in 95 per cent (n = 102) of specimens in upper antral mucopeptic glands and deep foveolar cells of the gastric pits but not in intestinal metaplasia. There was a significant statistical correlation between pS2 expression and extent of tumour growth (pT state) and expression of pepsinogen II by the tumours. There was no statistical correlation with clinical features such as patient age or sex or other pathological parameters (tumour stage, size, grade, and localization or growth pattern according to histological classification). There were no statistically significant differences in survival times between patients with pS2-positive and pS2-negative tumours. In contrast to findings concerning breast cancer, pS2 expression in gastric carcinomas had no influence on the patient's prognosis. On the other hand, strong expression of pS2 by surface epithelium of normal gastric mucosa may indicate that pS2 might play a role in physiological cell renewal of normal gastric mucosa.
对120例连续的胃癌患者进行了pS2蛋白（pS2）检测。这项免疫组织化学研究发现，48%（n = 58）的癌组织中有pS2表达。在95%（n = 102）的标本中，胃窦上部黏膜消化腺和胃小凹深部小窝细胞的正常胃黏膜中也检测到pS2表达，但在肠化生中未检测到。pS2表达与肿瘤生长范围（pT分期）及肿瘤组织中胃蛋白酶原II的表达之间存在显著的统计学相关性。与患者年龄、性别等临床特征或其他病理参数（肿瘤分期、大小、分级以及根据组织学分类的定位或生长方式）无统计学相关性。pS2阳性和pS2阴性肿瘤患者的生存时间无统计学显著差异。与乳腺癌的研究结果相反，胃癌中pS2表达对患者预后无影响。另一方面，正常胃黏膜表面上皮细胞中pS2的强表达可能表明pS2可能在正常胃黏膜的生理细胞更新中发挥作用。
