Barkai G, Reichman B, Kokia E, Segal P, Lusky A, Goldman B, Mashiach S
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel.
J Perinat Med. 1994;22(2):107-11. doi: 10.1515/jpme.1994.22.2.107.
Hypertensive disorders in pregnancy are associated with an increase in serum lipid fractions. Fluorescence Polarization (FP) of lipids in the serum of 80 hypertensive pregnant patients at full term was compared to measurements in a control group of 71 healthy pregnant volunteers. In addition, the FP values were correlated with measurements of serum lipid fraction in 34 hypertensive and 17 control patients. Both chronic hypertension and pregnancy induced hypertensive (PIH) subjects had significantly reduced serum FP values compared to the control group. This difference was however present only in the severely hypertensive patients, independent of the etiology of this disorder. Highly significant correlations were present between the FP values and serum level of Triglycerides r = -0.85, Very Low Density Lipoprotein r = -0.76, and Low Density Lipoprotein r = 0.53. Serum FP values appear to reflect the change in the lipoprotein pattern present in pregnant patients with hypertensive disorders. This change appears to reflect the severity of the condition rather than the etiology of the hypertension.
妊娠期高血压疾病与血清脂质成分增加有关。对80例足月高血压孕妇血清脂质的荧光偏振（FP）进行了测定，并与71例健康孕妇志愿者对照组进行了比较。此外，还对34例高血压患者和17例对照患者的FP值与血清脂质成分测量值进行了相关性分析。与对照组相比，慢性高血压患者和妊娠高血压（PIH）患者的血清FP值均显著降低。然而，这种差异仅存在于重度高血压患者中，与该疾病的病因无关。FP值与甘油三酯血清水平（r = -0.85）、极低密度脂蛋白（r = -0.76）和低密度脂蛋白（r = 0.53）之间存在高度显著的相关性。血清FP值似乎反映了患有高血压疾病的孕妇脂蛋白模式的变化。这种变化似乎反映了病情的严重程度，而非高血压的病因。
