Kokia E, Barkai G, Reichman B, Segal P, Goldman B, Mashiach S
Department of Obstetrics and Gynecology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.
J Perinat Med. 1990;18(6):473-8. doi: 10.1515/jpme.1990.18.6.473.
Plasma lipoprotein, cholesterol and triglycerides were determined in 34 hypertensive pregnant patients and in 17 healthy full term pregnant women. Pregnancy induced hypertension was diagnosed in 21 patients and chronic hypertension in the remaining 13 women. Serum triglyceride levels were significantly elevated in the hypertensive patients. This elevation was not influenced by either the severity or the etiology of the hypertension. The total cholesterol/HDL and the LDL/HDL ratios were significantly elevated in the severely hypertensive patients, and furthermore the LDL/HDL ratio was elevated in patients receiving anti-hypertensive treatment. The lipid profiles found in hypertensive pregnant patients could be associated with enhancement of pathological lipid deposition in predisposed vessels such as the uterine spiral arteries. Furthermore, the hypertriglyceridemia found in the hypertensive patients may be associated with the hypercoagulability reported in pregnancy induced hypertension.
对34例高血压孕妇和17例健康足月孕妇进行了血浆脂蛋白、胆固醇和甘油三酯检测。21例患者被诊断为妊娠高血压，其余13例为慢性高血压。高血压患者的血清甘油三酯水平显著升高。这种升高不受高血压严重程度或病因的影响。重度高血压患者的总胆固醇/高密度脂蛋白和低密度脂蛋白/高密度脂蛋白比值显著升高，此外，接受抗高血压治疗的患者低密度脂蛋白/高密度脂蛋白比值也升高。高血压孕妇的血脂谱可能与子宫螺旋动脉等易感血管中病理性脂质沉积的增加有关。此外，高血压患者中发现的高甘油三酯血症可能与妊娠高血压中报道的高凝状态有关。
