Bang G, Donath K, Thoresen S, Clausen O P
Department of Oral Pathology and Forensic Odontology, University of Bergen, Norway.
J Oral Pathol Med. 1994 Aug;23(7):291-7. doi: 10.1111/j.1600-0714.1994.tb00064.x.
Malignant salivary gland tumors are rare, constitute a heterogeneous group and are often difficult to diagnose histologically. This is borne out by the fact that in the present study 43.2% of 118 salivary gland tumors originally diagnosed as mucoepidermoid, acinic cell and adenoid cystic carcinomas had their original diagnosis altered upon reclassification. Patients with confirmed adenoid cystic carcinomas had a much worse prognosis than those with mucoepidermoid and acinic cell carcinomas. DNA flow cytometry showed that very few of the above mentioned three types of malignant neoplasms revealed aneuploid DNA stemlines, indicating that this is not a relevant prognostic tumor marker within the groups. However, several of the tumors that had their diagnosis changed, mostly to undifferentiated adeno- or squamous cell carcinomas, showed aneuploid DNA stemlines. The survival time of patients with aneuploid tumors was considerably reduced compared to those with diploid tumors. Among confirmed acinic cell, mucoepidermoid and adenoid cystic carcinomas the S-phase fraction was a significant prognostic factor, as it was among all tumors examined. This indicates that DNA aneuploidy and S-phase fractions are potential prognostic factors for malignant salivary gland tumors, and that DNA flow cytometry may assist the characterization of such tumors.
恶性唾液腺肿瘤较为罕见，构成一个异质性群体，且在组织学上往往难以诊断。本研究中118例最初诊断为黏液表皮样癌、腺泡细胞癌和腺样囊性癌的唾液腺肿瘤，有43.2%在重新分类后其最初诊断发生了改变，这一事实证实了上述情况。确诊为腺样囊性癌的患者预后比黏液表皮样癌和腺泡细胞癌患者差得多。DNA流式细胞术显示，上述三种类型的恶性肿瘤中很少有显示非整倍体DNA干系的，这表明在这些肿瘤组中这不是一个相关的预后肿瘤标志物。然而，一些诊断发生改变的肿瘤，大多变为未分化腺癌或鳞状细胞癌，显示出非整倍体DNA干系。与二倍体肿瘤患者相比，非整倍体肿瘤患者的生存时间显著缩短。在确诊的腺泡细胞癌、黏液表皮样癌和腺样囊性癌中，S期细胞分数是一个显著的预后因素，在所有检查的肿瘤中也是如此。这表明DNA非整倍体和S期细胞分数是恶性唾液腺肿瘤的潜在预后因素，并且DNA流式细胞术可能有助于此类肿瘤的特征描述。
