Zhang F, Oliva A, Kao S D, Newlin L, Buncke H J
Harry J. Buncke Microsurgical laboratory, Davies Medical Center, San Francisco, California 94114.
J Reconstr Microsurg. 1994 Jul;10(4):229-33. doi: 10.1055/s-2007-1006589.
This study utilizes the rat free groin-flap model to evaluate the survival of free flaps following revascularization with interpositional vein grafts. One hundred and fifty-three Sprague-Dawley rats were divided into a control group in which the groin flap was revascularized by simple end-to-end anastomosis, and three experimental groups revascularized with 10-mm, size-matched, interpositional, vein grafts to the femoral artery (Experimental Group 1), to the femoral vein (Experimental Group 2), and to both arterial and venous femoral vessels (Experimental Group 3). No statistically significant difference was noted in survival rates, when the experimental groups were compared to the control group (p1 = 0.619, p2 = 0.677, p3 = 0.666). As demonstrated by this study, free-tissue transfers in the rat, utilizing 10-mm, interpositional, vein grafts that are size-matched, and performed in a controlled laboratory setting, have the same survival rates as those revascularized by primary arterial and venous repairs.
本研究采用大鼠腹股沟游离皮瓣模型，以评估采用间置静脉移植进行血管重建后游离皮瓣的存活情况。153只Sprague-Dawley大鼠被分为对照组，其中腹股沟皮瓣通过单纯端端吻合进行血管重建；三个实验组，分别采用10毫米、尺寸匹配的间置静脉移植至股动脉（实验组1）、股静脉（实验组2）以及股动静脉（实验组3）进行血管重建。将实验组与对照组比较时，未观察到存活率有统计学显著差异（p1 = 0.619，p2 = 0.677，p3 = 0.666）。如本研究所示，在大鼠中进行的游离组织移植，使用10毫米、尺寸匹配的间置静脉移植，并在受控的实验室环境中进行，其存活率与通过主要动静脉修复进行血管重建的存活率相同。
