Leong K H, Koh E T, Feng P H, Boey M L
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
J Rheumatol. 1994 Jul;21(7):1264-7.
To determine the prevalence of abnormal lipid profiles in 100 consecutive patients with systemic lupus erythematosus (SLE) and the role of potential risk factors.
Fasting lipid profiles were measured using an enzymatic method. Biodata noted for each patient included age, sex, race, presence of diabetes mellitus, thyroid disease, familial hyperlipidemia, smoking history, presence of nephritis or nephrotic syndrome, lupus activity as measured by the lupus activity criteria count (LACC), duration of SLE, use of antihypertensive agents and the current and cumulative dose of steroids. Statistical analysis was done using PC SAS software.
Seventy-three patients had abnormal lipid profiles. Patients with normal and abnormal profiles were comparable in age, sex, race, history of diabetes mellitus, familial hyperlipidemia, and smoking. Abnormal values of total cholesterol (TC), low density lipoprotein (LDL), triglycerides (TG) and TC/high density lipoprotein (HDL) were associated with renal involvement and high dose corticosteroids (> 30 mg prednisolone/day). HDL levels were significantly lower in patients receiving high dose corticosteroids (p < 0.05). In patients with active lupus disease but without renal disease, lipid abnormalities were not observed.
Abnormal lipid profiles are common in this group of patients with SLE. High dose steroids and the nephrotic syndrome are important contributing factors.
确定100例连续系统性红斑狼疮（SLE）患者血脂异常的患病率以及潜在危险因素的作用。
采用酶法测量空腹血脂水平。记录的每位患者的生物数据包括年龄、性别、种族、糖尿病、甲状腺疾病、家族性高脂血症、吸烟史、肾炎或肾病综合征的存在情况、根据狼疮活动标准计数（LACC）测量的狼疮活动度、SLE病程、抗高血压药物的使用情况以及类固醇的当前和累积剂量。使用PC SAS软件进行统计分析。
73例患者存在血脂异常。血脂正常和异常的患者在年龄、性别、种族、糖尿病史、家族性高脂血症和吸烟方面具有可比性。总胆固醇（TC）、低密度脂蛋白（LDL）、甘油三酯（TG）以及TC/高密度脂蛋白（HDL）的异常值与肾脏受累和高剂量皮质类固醇（>30mg泼尼松龙/天）相关。接受高剂量皮质类固醇治疗的患者HDL水平显著降低（p<0.05）。在有活动性狼疮疾病但无肾脏疾病的患者中，未观察到血脂异常。
血脂异常在这组SLE患者中很常见。高剂量类固醇和肾病综合征是重要的促成因素。
