Carreño L, Monteagudo I, López-Longo F J, González C, Pérez T, Rodríguez Mahou M, Samson J, Lapointe N
Servicio de Reumatología, Hospital Universitario Gregorio Maranón, Madrid, Spain.
J Rheumatol. 1994 Jul;21(7):1344-6.
To study the presence of IgG and IgM anticardiolipin antibodies (aCL) in children with human immunodeficiency virus (HIV) infection and to determine their prevalence and clinical significance.
We studied 34 children with HIV infection: 26 patients were classified P-2, and 8 were P-1 according to the Centers for Disease Control classification. HIV transmission was from mother to child in 33 cases. aCL were measured by ELISA:
IgG aCL were found in 28 (82%) and IgM aCL in 7 (20%). No difference in frequency and levels was found between class P-2 (85%, mean 54.5 PL units) and class P-1 (75%, mean 50.3 PL units). aCL were not related to the duration of the infection, clinical stage of disease, or with events like opportunistic infections. Children from sexually infected or intravenous drug user mothers showed no differences.
As in adults, aCL are commonly found in children with HIV infection. The significance of this finding is still unclear.
研究人类免疫缺陷病毒（HIV）感染儿童中IgG和IgM抗心磷脂抗体（aCL）的存在情况，并确定其患病率及临床意义。
我们研究了34例HIV感染儿童：根据疾病控制中心的分类，26例患者为P - 2类，8例为P - 1类。33例HIV传播途径为母婴传播。采用酶联免疫吸附测定法（ELISA）检测aCL。
28例（82%）检测到IgG aCL，7例（20%）检测到IgM aCL。P - 2类（85%，平均54.5磷脂单位）和P - 1类（75%，平均50.3磷脂单位）在频率和水平上无差异。aCL与感染持续时间、疾病临床分期或机会性感染等事件无关。性传播感染母亲或静脉吸毒母亲所生儿童无差异。
与成人一样，HIV感染儿童中常见aCL。这一发现的意义仍不清楚。
