Molina J F, Gutierrez-Ureña S, Molina J, Uribe O, Richards S, De Ceulaer C, Garcia C, Wilson W A, Gharavi A E, Espinoza L R
Department of Medicine, Louisiana State University Medical Center (LSUMCI), New Orleans 70112-2822, USA.
J Rheumatol. 1997 Feb;24(2):291-6.
To investigate the prevalence of anticardiolipin antibodies (aCL) and isotype distribution and their clinical associations with the features of the antiphospholipid syndrome (APS) in 3 different ethnic groups of patients with systemic lupus erythematosus (SLE).
The study population consisted of 152 African-American, 136 Afro-Caribbean (Jamaican), and 163 Hispanic (Colombian) unselected patients with SLE. Serum samples were studied for the prevalence of aCL and isotype distribution. All aCL measurements were performed in the same laboratory by ELISA.
Positive results for 1 of the 3 aCL isotypes were found in 42 African-Americans (28%), 28 Afro-Caribbeans (21%), and 43 Hispanics (26%). IgG aCL was the dominant isotype in Hispanic and African-American patients, while IgA was the dominant isotype in Afro-Caribbeans. Of note, IgA aCL was found in all Afro-Caribbean patients who were aCL positive, while only 3 patients in this group had IgG aCL and 2 had IgM aCL. Clinical features of the APS were found to correlate better in Hispanics than in African-Americans and Afro-Caribbean patients with aCL isotypes.
Our data suggest the existence of ethnic differences in the prevalence and isotype distribution of aCL as well as in their clinical relevance in patients with SLE. Further studies of the role of genetic and/or environmental factors in the observed differences are required.
调查系统性红斑狼疮（SLE）患者3个不同种族群体中抗心磷脂抗体（aCL）的患病率、亚型分布及其与抗磷脂综合征（APS）特征的临床关联。
研究人群包括152名非裔美国人、136名非洲加勒比地区（牙买加）人和163名西班牙裔（哥伦比亚）未经过挑选的SLE患者。对血清样本进行aCL患病率及亚型分布研究。所有aCL检测均在同一实验室采用酶联免疫吸附测定法（ELISA）进行。
在42名非裔美国人（28%）、28名非洲加勒比地区人（21%）和43名西班牙裔（26%）患者中发现3种aCL亚型中的1种呈阳性结果。IgG aCL是西班牙裔和非裔美国患者中的主要亚型，而IgA是非洲加勒比地区患者中的主要亚型。值得注意的是，在所有aCL阳性的非洲加勒比地区患者中均发现了IgA aCL，而该组中只有3名患者有IgG aCL，2名患者有IgM aCL。与非裔美国人和非洲加勒比地区aCL亚型患者相比，西班牙裔患者中APS的临床特征相关性更好。
我们的数据表明，aCL的患病率、亚型分布及其在SLE患者中的临床相关性存在种族差异。需要进一步研究遗传和/或环境因素在观察到的差异中的作用。
