Zonana-Nacach A, Jiménez-Balderas F J, Martínez-Osuna P, Mintz G
Departamento de Reumatología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México.
J Rheumatol. 1994 Jul;21(7):1352-6.
Pyoderma gangrenosum is a chronic ulceronecrotic inflammatory cutaneous disorder that can be associated with diseases such as rheumatoid arthritis (RA). No definitive treatment exists for this condition; steroids have been the mainstay of therapy, and the addition of immunosuppressives has been advocated. We describe 2 patients with pyoderma gangrenosum occurring in the setting of RA who, in addition to steroids, received pulse intravenous cyclophosphamide and had a remarkably good and lasting response. This is the first report of such a therapeutic approach. The pertinent literature is discussed. We conclude that pulse cyclophosphamide is another possible therapy for pyoderma gangrenosum.
坏疽性脓皮病是一种慢性溃疡性坏死性炎性皮肤病，可与类风湿关节炎（RA）等疾病相关。目前尚无针对这种疾病的确切治疗方法；类固醇一直是主要治疗手段，有人主张加用免疫抑制剂。我们描述了2例在类风湿关节炎背景下发生坏疽性脓皮病的患者，他们除了接受类固醇治疗外，还接受了静脉注射环磷酰胺冲击治疗，且反应非常良好且持久。这是关于这种治疗方法的首例报告。文中讨论了相关文献。我们得出结论，环磷酰胺冲击治疗是坏疽性脓皮病的另一种可能的治疗方法。
