Gartner S, Liu Y, Polonis V, Lewis M G, Elkins W R, Hunter E A, Miao J, Corts K J, Eddy G A
Henry M. Jackson Foundation Research Laboratory, Rockville, MD 20850.
J Med Primatol. 1994 Feb-May;23(2-3):155-63. doi: 10.1111/j.1600-0684.1994.tb00117.x.
In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV-1. T lymphocytes from pigtailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV-1 isolates were unable to productively infect pigtailed macaque cells. Inoculation of autologous, HIV-1 expressing cells led to establishment of persistent infection in pigtailed macaques as evidenced by recovery of infectious virus and development of virus-specific antibody responses.
进行了体外感染性实验，以评估来自不同猴种的细胞对HIV-1的易感性。猪尾猕猴的T淋巴细胞对感染敏感，而恒河猴或食蟹猴的T淋巴细胞则不敏感，但病毒表达有限。大多数HIV-1分离株无法有效感染猪尾猕猴细胞。接种自体表达HIV-1的细胞导致猪尾猕猴中建立持续感染，这可通过感染性病毒的回收和病毒特异性抗体反应的发展得到证明。
