Benveniste R E, Roodman S T, Hill R W, Knott W B, Ribas J L, Lewis M G, Eddy G A
Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21702-1201.
J Med Primatol. 1994 Feb-May;23(2-3):83-8. doi: 10.1111/j.1600-0684.1994.tb00106.x.
The macaque infectious dose (MID) of a single-cell clone of simian immunodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one macaques were inoculated with 10-fold dilutions of the virus stock (three or four animals per dose). The virologic and clinical status of these animals was monitored for 26 weeks. The 25% MID (MID25) occurred at a 10(5)-fold dilution of the viral stock.
