Lohman B L, McChesney M B, Miller C J, Otsyula M, Berardi C J, Marthas M L
California Regional Primate Research Center, University of California, Davis 95616.
J Med Primatol. 1994 Feb-May;23(2-3):95-101. doi: 10.1111/j.1600-0684.1994.tb00108.x.
An effective AIDS vaccine must protect against sexual transmission of human immunodeficiency virus (HIV). Therefore, vaccine regimens which stimulate antiviral immunity in the genital tract as well as in peripheral blood and systemic lymphoid tissues are needed. Here, we describe a method of immunization by direct inoculation of the vaginal submucosa with a live attenuated SIV, SIVmac1A11. Immunization by this route generated low levels of SIV-specific IgG and IgA antibodies in serum and vaginal secretions and viral specific cytotoxic T lymphocyte (CTL) activity in peripheral blood.
一种有效的艾滋病疫苗必须能够预防人类免疫缺陷病毒（HIV）的性传播。因此，需要能在生殖道以及外周血和全身淋巴组织中激发抗病毒免疫的疫苗方案。在此，我们描述了一种通过向阴道黏膜下层直接接种减毒活猴免疫缺陷病毒（SIV）SIVmac1A11进行免疫的方法。通过这种途径进行免疫可在血清和阴道分泌物中产生低水平的SIV特异性IgG和IgA抗体，并在外周血中产生病毒特异性细胞毒性T淋巴细胞（CTL）活性。
