Lambert P A, Smith A R
Microbios. 1976;15(61-62):199-202.
Studies on the uptake of the antimicrobial agent N-dodecyldiethanolamine by Escherichia coli show that it rapidly penetrates the cell wall and damages the cytoplasmic membrane. Membrane damage is evident from the induced release of potassium ions and other cytoplasmic components from whole cells and from the lytic effect upon isolated spheroplasts. Concentrations of 0.4 mM and below lyse spheroplasts whereas higher concentrations cause coagulation of the cytoplasm which prevents lysis. The effect of membrane damage upon glucose oxidation in whole cells is also dependent upon the concentration of dodecyldiethanolamine. Concentrations of 0.4 mM and below stimulate oxygen uptake and higher concentrations inhibit it.
对大肠杆菌摄取抗菌剂N - 十二烷基二乙醇胺的研究表明，它能迅速穿透细胞壁并损害细胞质膜。从全细胞中钾离子和其他细胞质成分的诱导释放以及对分离的原生质球的裂解作用可以明显看出膜损伤。0.4 mM及以下的浓度会使原生质球裂解，而较高浓度会导致细胞质凝固，从而阻止裂解。膜损伤对全细胞中葡萄糖氧化的影响也取决于十二烷基二乙醇胺的浓度。0.4 mM及以下的浓度会刺激氧气摄取，而较高浓度则会抑制氧气摄取。
