de Peyster A, Willis W O, Liebhaber M
Division of Occupational and Environmental Health, Graduate School of Public Health, San Diego State University, CA 92182-0405.
J Toxicol Clin Toxicol. 1994;32(6):683-96. doi: 10.3109/15563659409017975.
Plasma and red blood cell cholinesterase activity in blood samples from 259 pregnant women and cord blood from some of their newborn were compared with samples from 25 nonpregnant female volunteers and with laboratory norms (Ellman method). Plasma cholinesterase was significantly lower (p < 0.05) and red blood cell cholinesterase higher (p < 0.05) in pregnant women than in nonpregnant controls in a repeated measures analysis. By the sixth post-partum week, both plasma and red blood cell cholinesterase were similar to nonpregnant control activity. Fetal cord red blood cell cholinesterase activity was also lower than in nonpregnant women, but plasma levels were not significantly different. When compared with standard laboratory normal ranges, most (98-100%) plasma cholinesterase values in pregnant women and newborn were within range, whereas the majority (59-87%, depending on trimester) of red blood cell levels were above range in pregnancy and below range in 53% of newborns. A low red blood cell cholinesterase in pregnant women is more consistent with a possible overexposure to anticholinesterases than a low plasma cholinesterase. Periods of altered sensitivity to specific cholinesterase inhibiting drugs and environmental agents are suggested by these findings.
将259名孕妇的血样及部分新生儿的脐带血中的血浆和红细胞胆碱酯酶活性，与25名非孕女性志愿者的样本以及实验室标准值（埃尔曼法）进行了比较。重复测量分析显示，孕妇的血浆胆碱酯酶显著降低（p < 0.05），红细胞胆碱酯酶则升高（p < 0.05）。产后第六周时，血浆和红细胞胆碱酯酶均与非孕对照组活性相似。胎儿脐带红细胞胆碱酯酶活性也低于非孕女性，但血浆水平无显著差异。与标准实验室正常范围相比，孕妇和新生儿的大多数（98 - 100%）血浆胆碱酯酶值在范围内，而红细胞水平的大多数（59 - 87%，取决于孕期）在孕期高于范围，53%的新生儿低于范围。孕妇红细胞胆碱酯酶水平低比血浆胆碱酯酶水平低更可能与抗胆碱酯酶药物暴露过量有关。这些发现提示了对特定胆碱酯酶抑制药物和环境因素敏感性改变的时期。
