Chan L
Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Malays J Pathol. 1995 Dec;17(2):87-9.
The spectrophotometric method of Ellman was used to determine cholinesterase (ChE) levels in plasma and whole blood in elderly patients and umbilical cord blood of newborn infants. The mean +/- SD for plasma and whole blood ChE levels were 2.24 +/- 0.58 micromol/min/ml and 4.38 +/- 0.65 micromol/min/ml respectively in a group of healthy elderly patients (n = 25). The mean +/- SD for plasma and whole blood ChE levels were 2.23 +/- 0.77 and 3.31 +/- 0.56 respectively in cord blood of healthy full term newborn infants (n = 25). In a group of healthy adult blood donors the general mean +/- SD for plasma and whole blood ChE have been shown to be 2.71 +/- 0.75 and 4.87 +/- 0.73 micromol/min/ml respectively. Statistical analysis revealed that the mean levels of plasma and whole blood ChE in elderly, newborn infants and adults were different (p < 0.001). However, there was no statistical difference between the mean level of plasma ChE in elderly and cord blood but each shared statistically significant difference when compared to the mean level in adults. The mean activity of whole blood ChE in the 3 groups was different from one another. Theoretically, decreased levels of ChE would suggest a careful assessment of drugs that are hydrolysed by ChE.
采用埃尔曼分光光度法测定老年患者血浆和全血以及新生儿脐带血中的胆碱酯酶（ChE）水平。一组健康老年患者（n = 25）血浆和全血ChE水平的均值±标准差分别为2.24±0.58微摩尔/分钟/毫升和4.38±0.65微摩尔/分钟/毫升。健康足月新生儿脐带血（n = 25）血浆和全血ChE水平的均值±标准差分别为2.23±0.77和3.31±0.56。在一组健康成年献血者中，血浆和全血ChE的总体均值±标准差分别显示为2.71±0.75和4.87±0.73微摩尔/分钟/毫升。统计分析显示，老年患者、新生儿和成年人血浆和全血ChE的平均水平存在差异（p < 0.001）。然而，老年患者血浆ChE的平均水平与脐带血之间无统计学差异，但与成年人的平均水平相比，二者均存在统计学显著差异。三组全血ChE的平均活性彼此不同。从理论上讲，ChE水平降低提示需谨慎评估由ChE水解的药物。
