一类利用相关磷酸盐转运蛋白进入细胞的逆转录病毒家族。
A family of retroviruses that utilize related phosphate transporters for cell entry.
作者信息
Miller D G, Miller A D
机构信息
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
出版信息
J Virol. 1994 Dec;68(12):8270-6. doi: 10.1128/JVI.68.12.8270-8276.1994.
Abstract
The amphotropic murine retrovirus receptor Ram-1 shows significant sequence similarity to the gibbon ape leukemia virus (GALV) receptor Glvr-1, and both of these cell surface virus receptors normally function as sodium-dependent phosphate symporters. However, Ram-1 from humans or rats does not serve as a receptor for GALV, and Glvr-1 from humans does not serve as a receptor for amphotropic virus. Here we show that the murine retrovirus 10A1 can enter cells by using either Glvr-1 or Ram-1. Furthermore, we have constructed Ram-1/Glvr-1 hybrid receptors that allow entry of both GALV and amphotropic virus. While GALV and amphotropic virus are in separate interference groups when assayed on human cells, they do interfere with each other in cells expressing the hybrid receptor. These results indicate a close functional relationship between retroviruses that utilize members of this newly defined receptor family and provide a molecular explanation for nonreciprocal and cell type-specific interference observed for some retrovirus classes.
摘要
双向性鼠逆转录病毒受体Ram-1与长臂猿白血病病毒（GALV）受体Glvr-1具有显著的序列相似性，并且这两种细胞表面病毒受体通常作为钠依赖性磷酸盐共转运体发挥作用。然而，来自人类或大鼠的Ram-1不能作为GALV的受体，来自人类的Glvr-1也不能作为双向性病毒的受体。在此我们表明，鼠逆转录病毒10A1可以通过使用Glvr-1或Ram-1进入细胞。此外，我们构建了Ram-1/Glvr-1杂交受体，其允许GALV和双向性病毒进入。当在人类细胞上进行检测时，GALV和双向性病毒处于不同的干扰组，但在表达杂交受体的细胞中它们确实会相互干扰。这些结果表明利用这个新定义的受体家族成员的逆转录病毒之间存在密切的功能关系，并为某些逆转录病毒类别中观察到的非相互性和细胞类型特异性干扰提供了分子解释。
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