Wilson C A, Eiden M V, Anderson W B, Lehel C, Olah Z
Laboratory of Molecular Tumor Biology, Food and Drug Administration, Rockville, Maryland 20892.
J Virol. 1995 Jan;69(1):534-7. doi: 10.1128/JVI.69.1.534-537.1995.
Previously, we showed that the amphotropic receptor homolog in hamster cells functions as a receptor not only for amphotropic murine leukemia viruses and 10A1 murine leukemia virus but also for gibbon ape leukemia virus (C.A. Wilson, K. B. Farrell, and M. V. Eiden, J. Virol. 68:7697-7703, 1994). Here, we demonstrate that this receptor functions as a sodium-dependent Pi transporter and that Na-Pi uptake can be specifically blocked following infection with either amphotropic murine leukemia virus, 10A1 murine leukemia virus, or gibbon ape leukemia virus.
此前,我们发现仓鼠细胞中的双嗜性受体同源物不仅作为双嗜性鼠白血病病毒和10A1鼠白血病病毒的受体,还作为长臂猿白血病病毒的受体(C.A. 威尔逊、K.B. 法雷尔和M.V. 艾登,《病毒学杂志》68:7697 - 7703,1994年)。在此,我们证明该受体作为一种钠依赖性磷酸盐转运体发挥作用,并且在用双嗜性鼠白血病病毒、10A1鼠白血病病毒或长臂猿白血病病毒感染后,钠 - 磷酸盐摄取可被特异性阻断。