表皮生长因子受体不是痘苗病毒的受体。
The epidermal growth factor receptor is not a receptor for vaccinia virus.
作者信息
Hügin A W, Hauser C
机构信息
Clinique de Dermatologie, Hôpital Cantonal Universitaire, Geneva, Switzerland.
出版信息
J Virol. 1994 Dec;68(12):8409-12. doi: 10.1128/JVI.68.12.8409-8412.1994.
Abstract
It has been suggested that the epidermal growth factor receptor (EGFR) is a receptor for vaccinia virus. Other reports, although not specifically addressing this question, did not support such a role for the EGFR. We addressed this issue by using wild-type virus and a virus growth factor deletion mutant, as well as sets of cells that do not express EGFR or have been transfected with the human gene for EGFR. The expression of virus growth factor by vaccinia virus or of EGFR by the target cells influenced neither virus adsorption to cells nor penetration. These results indicate that the EGFR is not a receptor for vaccinia virus.
摘要
有人提出表皮生长因子受体（EGFR）是痘苗病毒的受体。其他报告虽未专门探讨这个问题，但不支持EGFR有这样的作用。我们通过使用野生型病毒和病毒生长因子缺失突变体，以及不表达EGFR或已转染人EGFR基因的细胞系来研究这个问题。痘苗病毒表达病毒生长因子或靶细胞表达EGFR，既不影响病毒对细胞的吸附，也不影响其穿透。这些结果表明，EGFR不是痘苗病毒的受体。
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