Selman S H, Keck R W
Department of Urology, Medical College of Ohio, Toledo 43699-0008.
J Urol. 1994 Dec;152(6 Pt 1):2129-32. doi: 10.1016/s0022-5347(17)32337-6.
A pilot study was undertaken to determine the effect of transurethral light on photosensitized periurethral prostatic tissue in the dog. Initial studies demonstrated that a sufficient level of the photosensitizer tin (II) etiopurpurin dichloride, SnET2, was present in the canine prostate 24 hours after intravenous administration to create a photodynamic effect. Gross and histologic examination of SnET2 photosensitized prostates treated transurethrally with 285 joules per cm. of red light (660 nm.) showed hemorrhagic necrosis as much as 1 cm. from the urethral wall. Three weeks after treatment, circumferential glandular atrophy was evident within the treatment area. The urethral mucosa, which was histologically absent at the 48-hour interval, regenerated by 3 weeks. Transurethral photodynamic treatment of the prostate is feasible, and its use for the treatment of benign prostatic hyperplasia warrants further investigation.
进行了一项初步研究，以确定经尿道光对犬光敏性尿道周围前列腺组织的影响。初步研究表明，静脉注射后24小时，犬前列腺中存在足够水平的光敏剂二氯锡（II）依替泊卟啉（SnET2），可产生光动力效应。对经尿道用每平方厘米285焦耳的红光（660纳米）处理的SnET2光敏前列腺进行大体和组织学检查，结果显示距尿道壁1厘米处出现出血性坏死。治疗三周后，治疗区域内可见环状腺萎缩。尿道黏膜在48小时间隔时组织学上不存在，但在3周时再生。经尿道前列腺光动力治疗是可行的，其用于治疗良性前列腺增生值得进一步研究。
