苦楝叶提取物对小鼠腹腔渗出细胞的体外抗吞噬作用。

In vitro antiphagocytic effect of Melia azedarach leaf extracts on mouse peritoneal exudate cells.

作者信息

Courrèges M C, Benencia F, Coto C E, Massouh E J, Coulombié F C

机构信息

Laboratory of Virology, Faculty of Sciences, University of Buenos Aires, Argentina.

出版信息

J Ethnopharmacol. 1994 Jul 8;43(2):135-40. doi: 10.1016/0378-8741(94)90010-8.

DOI:10.1016/0378-8741(94)90010-8

PMID:7967653

Abstract

The effect of Melia azedarach L. (Meliaceae) leaf extract on the phagocytic capability and respiratory burst of mouse peritoneal exudate cells was studied. The extract inhibited the phagocytosis of opsonized sheep erythrocytes. This inhibition was both dose- and time-dependent and reverted 48 h after removing the extract from the culture medium. Furthermore, chemiluminescence in treated cells was also impaired using either receptor (opsonized zymosan) or post-receptor (PMA) stimuli.

摘要

研究了楝科植物苦楝叶提取物对小鼠腹腔渗出细胞吞噬能力和呼吸爆发的影响。该提取物抑制调理化绵羊红细胞的吞噬作用。这种抑制作用呈剂量和时间依赖性，且在从培养基中去除提取物48小时后恢复。此外，使用受体（调理化酵母聚糖）或受体后（佛波酯）刺激时，处理过的细胞中的化学发光也受到损害。