Winkelmann R K, Stevens J C
Department of Dermatology, Mayo Clinic Scottsdale, Arizona.
Mayo Clin Proc. 1994 Dec;69(12):1163-5. doi: 10.1016/s0025-6196(12)65769-3.
We describe a 62-year-old woman in whom skin biopsies verified the clinical diagnosis of granuloma annulare and neurologic and electromyographic studies confirmed the neurologic diagnosis of carpal tunnel syndrome. Short-term treatment with a low dose of chlorambucil taken orally was prescribed. Within weeks, the granuloma annulare had disappeared, and the clinical symptoms of carpal tunnel syndrome had resolved. Electromyography showed variable improvement at the end of treatment and resolution at 9-month follow-up. Our case confirms that short-term treatment of granuloma annulare and associated carpal tunnel syndrome with low-dose chlorambucil is successful.
我们描述了一位62岁女性，其皮肤活检证实了环状肉芽肿的临床诊断，神经学和肌电图研究证实了腕管综合征的神经学诊断。给予口服低剂量苯丁酸氮芥进行短期治疗。数周内，环状肉芽肿消失，腕管综合征的临床症状得到缓解。治疗结束时肌电图显示有不同程度改善，9个月随访时恢复正常。我们的病例证实，用低剂量苯丁酸氮芥短期治疗环状肉芽肿及相关的腕管综合征是成功的。
