Kossard S, Winkelmann R K
Dermatologica. 1979;158(6):443-50. doi: 10.1159/000250796.
5 of 6 adults with generalized granuloma annulare responded favorably to therapy with low-dose chlorambucil. 5 of the patients had lesions that were recurrent and long-standing and that resisted conventional modalities of therapy. Low-dose chlorambucil may be effective in a short-term therapy program but should be used only in patients with persistent, widespread, or unusual forms of generalized granuloma annulare. The program requires close patient and hematologic supervision.
6例泛发性环状肉芽肿成年患者中有5例对小剂量苯丁酸氮芥治疗反应良好。其中5例患者的皮损反复出现且病程长久，对传统治疗方式无效。小剂量苯丁酸氮芥可能在短期治疗方案中有效，但仅应用于患有持续性、广泛性或特殊形式泛发性环状肉芽肿的患者。该治疗方案需要对患者和血液学指标进行密切监测。
