[氯贝丁酯对大鼠组织脂肪酶活性的影响]
[Effect of clofibrate on tissue lipase activity in rats].
作者信息
Decoopman E, Sezille G, Dewailly P, Fruchart J C, Jaillard J
出版信息
Pathol Biol (Paris). 1976 Dec;24(10):691-3.
PMID:796791
Abstract
Given for 20 days at a concentration of 0.3% in the diet, clofibrate lowers serum triglyceride level and causes a 48% increase of lipoprotein lipase activity in rat fat pad, after feeding. This increase does not appear in the animals on fasting. These results agree with an effect of clofibrate upon membranous adenyl-cyclase of adipose tissue.
摘要
以0.3%的浓度添加到饲料中喂食20天，安妥明可降低大鼠血清甘油三酯水平，并使喂食后大鼠脂肪垫中的脂蛋白脂肪酶活性提高48%。禁食的动物未出现这种增加。这些结果与安妥明对脂肪组织膜性腺苷酸环化酶的作用一致。
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