Malyszko J, Urano T, Knofler R, Ihara H, Takada Y, Takada A
Department of Physiology, Hamamatsu University School of Medicine, Japan.
Life Sci. 1994;55(21):1619-23. doi: 10.1016/0024-3205(94)00328-9.
We have studied relationships between serum lipids, plasma serotonin (5-hydroxytryptamine, 5-HT), platelet aggregation in the platelet-rich plasma (PRP), and some fibrinolytic parameters in healthy volunteers. LDL was positively related to 5-HT-induced platelet aggregation. Higher serum HDL levels were related to higher fibrinolytic activity expressed by shorter euglobulin clot lysis time (ECLT). No correlation existed between serum lipids and plasma 5-HT. Plasma 5-HT was found to be related to tissue plasminogen activator (t-PA), suggesting some link between plasma serotonin and the release of t-PA from endothelial cells. There were mutual relations among fibrinolytic parameters such as tissue plasminogen activator (t-PA) antigens, total plasminogen activator inhibitor-1 (PAI-1), t-PA-PAI-1 complex, free PAI-1, and ECLT. In conclusion higher LDL may be more thrombogenic due to enhanced 5-HT induced platelet aggregation whereas high HDL may be more protective against thrombosis due to enhancement of fibrinolysis.
我们研究了健康志愿者血清脂质、血浆血清素（5-羟色胺，5-HT）、富血小板血浆（PRP）中的血小板聚集以及一些纤溶参数之间的关系。低密度脂蛋白（LDL）与5-HT诱导的血小板聚集呈正相关。较高的血清高密度脂蛋白（HDL）水平与较短的优球蛋白凝块溶解时间（ECLT）所表示的较高纤溶活性相关。血清脂质与血浆5-HT之间不存在相关性。发现血浆5-HT与组织纤溶酶原激活物（t-PA）有关，提示血浆血清素与内皮细胞释放t-PA之间存在某种联系。纤溶参数如组织纤溶酶原激活物（t-PA）抗原、总纤溶酶原激活物抑制剂-1（PAI-1）、t-PA-PAI-1复合物、游离PAI-1和ECLT之间存在相互关系。总之，较高的LDL可能由于5-HT诱导的血小板聚集增强而更具血栓形成性，而高HDL可能由于纤溶增强而对血栓形成更具保护作用。
