Morrison V, Ashby J
Zeneca Central Toxicology Laboratory, Nr Macclesfield, Cheshire, UK.
Mutagenesis. 1994 Jul;9(4):367-75. doi: 10.1093/mutage/9.4.367.
All of the published mutagenicity data generated using the Muta Mouse (lacZ) and the Big Blue (lacI) transgenic mouse mutation assays have been re-presented in a standard format. To date, 26 chemicals have been evaluated in one or other of the assays, and eight tissues have been sampled. The present analysis should expedite the further validation of these assays. In particular, it is suggested that data on the present 26 chemicals should be consolidated rather than the generation of partial data sets on additional chemicals.
所有使用Muta小鼠（lacZ）和大蓝（lacI）转基因小鼠突变试验生成的已发表致突变性数据均已采用标准格式重新呈现。迄今为止，已经在其中一种或另一种试验中对26种化学物质进行了评估，并对八个组织进行了采样。目前的分析应能加快这些试验的进一步验证。特别是，建议整合目前这26种化学物质的数据，而不是生成关于其他化学物质的部分数据集。
