Biegon A, Eberling J L, Richardson B C, Roos M S, Wong S T, Reed B R, Jagust W J
Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Neurobiol Aging. 1994 Jul-Aug;15(4):393-7. doi: 10.1016/0197-4580(94)90070-1.
The involvement of the corpus callosum in aging and Alzheimer's disease (AD) is not clear. We measured cross sectional areas of the entire corpus callosum (CC), as well as the front 20% (genu), middle 60% (body), and posterior 20% (splenium) of the structure from a midsagittal MRI slice in AD patients (N = 20), and young (N = 16) and old (N = 13) control subjects. We found that mean CC area in young controls was 570 +/- 107 mm2. Aging did not significantly affect the mean area of the CC (562 +/- 98 mm2). A small, significant reduction was seen in AD in comparison to the young control group (480 +/- 133 mm2). However, AD is accompanied by a large and statistically significant reduction in the genu area in comparison to both young and old control subjects. A trend toward an age-dependent reduction in the body area is also accentuated in AD patients who showed significantly smaller callosal bodies than young controls. We conclude that selective changes within corpus callosum accompany aging and AD pathology.
胼胝体在衰老和阿尔茨海默病（AD）中的作用尚不清楚。我们从矢状面MRI切片测量了AD患者（N = 20）、年轻对照组（N = 16）和老年对照组（N = 13）中整个胼胝体（CC）以及该结构的前20%（膝部）、中间60%（体部）和后20%（压部）的横截面积。我们发现年轻对照组的平均CC面积为570±107mm²。衰老并未显著影响CC的平均面积（562±98mm²）。与年轻对照组相比，AD组出现了小幅度但显著的面积减少（480±133mm²）。然而，与年轻和老年对照组相比，AD伴有膝部面积大幅且具有统计学意义的减少。在AD患者中，胼胝体体部面积随年龄增长而减少的趋势也更为明显，这些患者的胼胝体体部明显小于年轻对照组。我们得出结论，胼胝体内的选择性变化伴随着衰老和AD病理过程。
