Groenendaal F, Meiners L C, Gooskens R, de Vries L S
Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
Neuropediatrics. 1994 Jun;25(3):154-7. doi: 10.1055/s-2008-1073014.
On the basis of detection of cardiac tumours and an intracerebral subependymal mass, the diagnosis of tuberous sclerosis was made in a fullterm neonate. To evaluate cerebral metabolism cerebral mass proton magnetic resonance spectroscopic imaging (1H-MRSI) was performed. A local decrease in N-acetyl-aspartate (NAA), and an increase in choline signals were found. Lactate could neither be demonstrated in the subependynal nodule, nor in the surrounding tissue, thereby rendering the possibility of a high-grade malignant tumour less likely. No major changes were found at 3 and 6 months of age. The present study demonstrates, that 1H-MRSI may be helpful in metabolic evaluation of cerebral masses in patients with tuberous sclerosis.
基于对心脏肿瘤和脑室内室管膜下肿块的检测，一名足月儿被诊断为结节性硬化症。为评估脑代谢，进行了脑部质子磁共振波谱成像（1H-MRSI）。发现N-乙酰天门冬氨酸（NAA）局部降低，胆碱信号增加。在室管膜下结节及其周围组织中均未检测到乳酸，因此高级别恶性肿瘤的可能性较小。在3个月和6个月大时未发现重大变化。本研究表明，1H-MRSI可能有助于结节性硬化症患者脑肿块的代谢评估。
