Post R M, Silberstein S D
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892.
Neurology. 1994 Oct;44(10 Suppl 7):S37-47.
For a specific subgroup of patients with migraine or affective illness who experience illness progression and drug tolerance, the amygdala kindling paradigm can be a useful, but nonhomologous, model. Although these patients do not have a seizure or seizure-like disorder, kindling has been used to examine the types of memory-like mechanisms that could underlie syndrome evolution in both migraine and affective illness. While the precipitants, symptomatology, duration of attack, and aura symptoms differ among epilepsy, migraine, and the affective disorders, all are paroxysmal dysregulations that partially share effective drug treatment. The principles of seizure progression presented here may apply to affective and migraine patients whose episodes progress from isolated and intermittent to more chronic or daily. These patients may also develop tolerance to long-term prophylactic treatments.
对于患有偏头痛或情感性疾病且经历病情进展和药物耐受性的特定亚组患者，杏仁核点燃范式可能是一种有用但不同源的模型。尽管这些患者没有癫痫发作或癫痫样疾病，但点燃已被用于研究可能是偏头痛和情感性疾病综合征演变基础的记忆样机制类型。虽然癫痫、偏头痛和情感障碍在诱发因素、症状学、发作持续时间和先兆症状方面有所不同，但它们都是阵发性调节异常，部分共享有效的药物治疗。这里提出的癫痫发作进展原则可能适用于发作从孤立和间歇性发展为更慢性或每日发作的情感性和偏头痛患者。这些患者也可能对长期预防性治疗产生耐受性。
