Tozawa F, Suda T, Dobashi I, Ohmori N, Kasagi Y, Demura H
Department of Medicine, Tokyo Women's Medical College, Japan.
Neurosci Lett. 1994 Jun 6;174(1):117-9. doi: 10.1016/0304-3940(94)90133-3.
To determine if there is a short negative feedback effect of hypothalamic ACTH-related peptides on corticotropin-releasing factor (CRF) release in vivo, we examined the effect of cerebroventricular injection of alpha-melanocyte-stimulating hormone (alpha MSH) on ACTH levels in plasma and the anterior pituitary and CRF levels in the median eminence of the hypothalamus in adrenalectomized or sham-operated rats under pentobarbital anesthesia. alpha MSH did not affect basal ACTH or CRF levels in sham operated rats. However, elevated plasma ACTH levels and CRF levels in the median eminence were decreased by central administration of alpha MSH in adrenalectomized rats. These results suggest that there is a short negative feedback effect of alpha MSH on CRF release and it appears only in the absence of a long negative feedback effect of glucocorticoids.
为了确定下丘脑促肾上腺皮质激素相关肽对体内促肾上腺皮质激素释放因子（CRF）释放是否存在短期负反馈效应，我们在戊巴比妥麻醉下，研究了脑室注射α-黑素细胞刺激素（α-MSH）对肾上腺切除或假手术大鼠血浆和垂体前叶促肾上腺皮质激素（ACTH）水平以及下丘脑正中隆起处CRF水平的影响。α-MSH对假手术大鼠的基础ACTH或CRF水平没有影响。然而，在肾上腺切除大鼠中，中枢给予α-MSH可降低升高的血浆ACTH水平和正中隆起处的CRF水平。这些结果表明，α-MSH对CRF释放存在短期负反馈效应，且这种效应仅在糖皮质激素的长期负反馈效应不存在时出现。
