Masliah E, Mallory M, Hansen L, DeTeresa R, Alford M, Terry R
Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla 92093-0624.
Neurosci Lett. 1994 Jun 6;174(1):67-72. doi: 10.1016/0304-3940(94)90121-x.
Extensive synaptic and neuritic alterations in the neocortex and limbic system are characteristically found in Alzheimer's disease (AD). However, it is not known how early in the development of the disease these alterations occur. For the present study, we compared the synaptic and neuritic alterations among cases classified clinically and neuropathologically as early, mild and advanced AD. In early AD there was a 20% loss of synaptophysin-immunoreactive presynaptic terminals in the outer molecular layer of the hippocampal dentate gyrus (but not in the neocortex and entorhinal cortex), accompanied by increased amyloid precursor protein (APP) and Alz50 immunoreactivity in hippocampal and entorhinal cortex pyramidal neurons. These results suggest that abnormal neuronal expression of APP and cytoskeletal proteins in early stages might be involved in the mechanisms of synaptic pathology in AD.
在阿尔茨海默病（AD）中，新皮质和边缘系统会出现广泛的突触和神经突改变，这是其典型特征。然而，目前尚不清楚这些改变在疾病发展的早期阶段是何时发生的。在本研究中，我们比较了临床上和神经病理学上分类为早期、轻度和晚期AD的病例之间的突触和神经突改变。在早期AD中，海马齿状回外分子层中突触素免疫反应性突触前终末有20%的丢失（但新皮质和内嗅皮质中没有），同时海马和内嗅皮质锥体神经元中的淀粉样前体蛋白（APP）和Alz50免疫反应性增加。这些结果表明，早期阶段APP和细胞骨架蛋白的异常神经元表达可能参与了AD突触病理学机制。
