West H L, Rebeck G W, Hyman B T
Neurology Service, Massachusetts General Hospital, Boston 02214.
Neurosci Lett. 1994 Jul 4;175(1-2):46-8. doi: 10.1016/0304-3940(94)91074-x.
Recent data have demonstrated genetic disequilibrium between inheritance of the apolipoprotein E (apoE) epsilon 4 allele and increased risk of Alzheimer disease. We tested the idea that inheritance of other allelic variations of apoE might also increase or decrease the risk of developing Alzheimer disease. We studied apoE genotypes in a large clinic based population of Alzheimer disease patients and age-compatible, tested control individuals. We confirm the genetic disequilibrium between apoE epsilon 4 and Alzheimer disease and now report that inheritance of apoE epsilon 2, another common variant of the apolipoprotein E gene, is negatively associated with risk of developing Alzheimer disease.
最近的数据表明，载脂蛋白E（apoE）ε4等位基因的遗传与阿尔茨海默病风险增加之间存在基因不平衡。我们测试了这样一种想法，即apoE的其他等位基因变异的遗传也可能增加或降低患阿尔茨海默病的风险。我们在一个以临床为基础的大量阿尔茨海默病患者群体以及年龄匹配的对照个体中研究了apoE基因型。我们证实了apoE ε4与阿尔茨海默病之间的基因不平衡，并且现在报告载脂蛋白E基因的另一个常见变异体apoE ε2的遗传与患阿尔茨海默病的风险呈负相关。
