抗生素治疗前从婴儿中分离出的潜在病原体的鼻咽部菌株的抗菌药敏性：对中耳炎管理的意义
Antimicrobial susceptibility of nasopharyngeal isolates of potential pathogens recovered from infants before antibiotic therapy: implications for the management of otitis media.
作者信息
Faden H, Doern G, Wolf J, Blocker M
机构信息
State University of New York, School of Medicine, Children's Hospital, Buffalo 14222.
出版信息
Pediatr Infect Dis J. 1994 Jul;13(7):609-12. doi: 10.1097/00006454-199407000-00005.
Antimicrobial susceptibility was determined for strains of Streptococcus pneumoniae, nontypable Haemophilus influenzae and Moraxella catarrhalis recovered from the nasopharynxes of children followed from birth. The bacteria tested were the first potential pathogens isolated from each child before any treatment with antibiotics. Minimal inhibitory concentrations of commonly used oral antibiotics demonstrated the following overall rates of resistance for (1) S. pneumoniae: penicillin 1.2% (intermediate susceptibility 4.8%), trimethoprim-sulfamethoxazole 20%; (2) nontypable H. influenzae: ampicillin 32%, cefaclor 17%; (3) M. catarrhalis: ampicillin 90%, trimethoprim-sulfamethoxazole 19%. Antibiotic regimens used for treatment of otitis media may have to be evaluated in light of changing antibiotic susceptibilities.
对从出生起就进行跟踪的儿童鼻咽部分离出的肺炎链球菌、不可分型流感嗜血杆菌和卡他莫拉菌菌株进行了药敏试验。所检测的细菌是每个儿童在接受任何抗生素治疗之前分离出的首批潜在病原体。常用口服抗生素的最低抑菌浓度显示出以下总体耐药率：（1）肺炎链球菌：青霉素1.2%（中介敏感4.8%），甲氧苄啶-磺胺甲恶唑20%；（2）不可分型流感嗜血杆菌：氨苄西林32%，头孢克洛17%；（3）卡他莫拉菌：氨苄西林90%，甲氧苄啶-磺胺甲恶唑19%。鉴于抗生素敏感性的变化，可能必须根据情况评估用于治疗中耳炎的抗生素方案。
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