Gan Chan-Fen, Gong Ren-Rong, Lin Jia, Li Zheng-Ke, Tang Hui, Huang Xin, Li Rong-Hui, Fang Ding-Zhi
Department of Biochemistry and Molecular Biology Laboratory, West China School of Preclinical and Forensic, Medicine, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):267-71, 275.
To investigate the effects of the short-term high-carbohydrate/low-fat (HC/LF) diet on the serum lipid ratios of healthy young subjects, which meant triglyceride to high-density lipoprotein cholesterol (TG/HDL-C), the logarithm of TG/HDL-C [log (TG/HDL-C)], low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C), and total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C).
56 healthy participants with the average age of (22.89 +/- 1.80) years took the normal diet for 7 days followed by HC/LF diet for 6 days. Venous blood samples in fasting were collected between 7 : 00 and 10 : 00 AM on the 1st, the 8th and 14th day, respectively. Serum concentrations of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were measured by regular methods. The ratios of TG/HDL-C, log (TG/HDL-C), LDL-C/HDL-C, and TC/ HDL-C were calculated.
After HC/LF diet, both TG/HDL-C and log (TG/HDL-C) increased significantly for females (P < 0.05). For the males, these two ratios were decreased although not significant in statistics. When BMI or WHR was taken into account, the two ratios increased significantly after HC/LF diet, but only for the normal females (P < 0.05), not for the females with overall or abdominal adiposity. No significant changes of TG/HDL-C and log(TG/HDL-C) after HC/LF diet were observed between the males with different BMI or WHR. TC/HDL-C and LDL-C/HDL-C decreased significantly (P < 0.05) after HC/LF diet, but these changes were not found to associate with gender, BMI or WHR.
The changes of TG/HDL-C and log (TG/HDL-C) induced by the short-term HC/LF diet are different in healthy young subjects with different gender, BMI or WHR, but there is no significant change happening to TC/HDL-C and LDL-C/HDL-C.
研究短期高碳水化合物/低脂（HC/LF）饮食对健康年轻受试者血脂比值的影响，这些血脂比值包括甘油三酯与高密度脂蛋白胆固醇之比（TG/HDL-C）、TG/HDL-C的对数[log (TG/HDL-C)]、低密度脂蛋白胆固醇与高密度脂蛋白胆固醇之比（LDL-C/HDL-C）以及总胆固醇与高密度脂蛋白胆固醇之比（TC/HDL-C）。
56名平均年龄为（22.89±1.80）岁的健康参与者先采用正常饮食7天，随后采用HC/LF饮食6天。分别在第1天、第8天和第14天上午7:00至10:00采集空腹静脉血样。采用常规方法测定血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）的浓度。计算TG/HDL-C、log (TG/HDL-C)、LDL-C/HDL-C和TC/HDL-C的比值。
HC/LF饮食后，女性的TG/HDL-C和log (TG/HDL-C)均显著升高（P<0.05）。对于男性，这两个比值有所下降，尽管统计学上不显著。当考虑BMI或腰臀比（WHR）时，HC/LF饮食后这两个比值显著升高，但仅在正常女性中如此（P<0.05），在总体肥胖或腹型肥胖女性中未出现这种情况。在不同BMI或WHR的男性中，HC/LF饮食后未观察到TG/HDL-C和log(TG/HDL-C)有显著变化。HC/LF饮食后，TC/HDL-C和LDL-C/HDL-C显著降低（P<0.05），但这些变化未发现与性别、BMI或WHR有关。
短期HC/LF饮食引起的TG/HDL-C和log (TG/HDL-C)变化在不同性别、BMI或WHR的健康年轻受试者中有所不同，但TC/HDL-C和LDL-C/HDL-C未发生显著变化。
