Wu J, Ishikawa N, Takeda T, Tanaka Y, Pan X Q, Sato M, Todoroki T, Hatakeyama R, Itai Y
Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Ann Nucl Med. 1995 Nov;9(4):229-35. doi: 10.1007/BF03168406.
The accuracy of measurement of the functional hepatic volume by single photon emission computed tomography (SPECT) with 99mTc-galactosyl serum albumin (99mTc-GAS) was evaluated. 99mTc-GSA planar scintigraphic images were obtained dynamically and the hepatic SPECT imaging was then performed in 25 patients with hepatobiliary tumors. The patients were divided into 4 groups with normal hepatic function, and mild, moderate and severe hepatic dysfunction. The functional hepatic volume determined by SPECT was compared with the morphological hepatic volume determined by compute tomography. The ratio of the hepatic volumes obtained by the two methods was calculated. The mean hepatic volume ratio was 96.6 +/- 2.3% in the normal hepatic function group and 95.9 +/- 2.2% in the mild dysfunction group (n.s.). In both the moderate and severe hepatic dysfunction groups, the hepatic volume ratio was smaller than that in the normal group (87.9 +/- 5.2%, p < 0.0001, and 71.9 +/- 7.6%, p < 0.0001, respectively). There was a linear correlation between the hepatic volume ration and various indices of reserve hepatic function, such as LHL15 (r = 0.83, p < 0.0001), HH15(r = 0.74, p < 0.0001), and ICG15 (r = 0.75, p < 0.0005). These results indicate that the hepatic volume ratio is proportional to the severity of hepatic dysfunction, and suggest that the functional hepatic volume measured with 99mTc-GSA faithfully reflects the functioning hepatocyte mass. 99mTc-GSA scintigraphy and hepatic SPECT therefore provide information regarding global and regional reserve hepatic function.
评估了采用99m锝-半乳糖基血清白蛋白（99mTc-GAS）单光子发射计算机断层扫描（SPECT）测量功能性肝体积的准确性。对25例肝胆肿瘤患者动态获取99mTc-GSA平面闪烁图像，随后进行肝脏SPECT成像。将患者分为肝功能正常、轻度肝功能不全、中度肝功能不全和重度肝功能不全4组。将SPECT测定的功能性肝体积与计算机断层扫描测定的形态学肝体积进行比较。计算两种方法测得的肝体积之比。肝功能正常组的平均肝体积比为96.6±2.3%，轻度肝功能不全组为95.9±2.2%（无显著差异）。中度和重度肝功能不全组的肝体积比均低于正常组（分别为87.9±5.2%，p<0.0001；71.9±7.6%，p<0.0001）。肝体积比与多种肝脏储备功能指标之间存在线性相关性，如LHL15（r=0.83，p<0.0001）、HH15（r=0.74，p<0.0001）和ICG15（r=0.75，p<0.0005）。这些结果表明肝体积比与肝功能不全的严重程度成正比，提示用99mTc-GSA测量的功能性肝体积忠实地反映了有功能的肝细胞数量。因此，99mTc-GSA闪烁扫描和肝脏SPECT可提供有关整体和局部肝脏储备功能的信息。
