Micali G, Nasca M R, Innocenzi D, Lembo D
Cattedra di Dermatologia, Universitá di Reggio Calabria, sede di Catanzaro, Italy.
Pediatr Dermatol. 1994 Sep;11(3):241-5. doi: 10.1111/j.1525-1470.1994.tb00594.x.
Agminated lentiginosis (AL) is characterized by numerous lentigines confined to a body segment, with a sharp demarcation at the midline. So far, only 13 cases have been reported in the literature. We report a 30-year-old woman with a multifocal AL. The cutaneous lesions first appeared at 5 years of age and gradually increased in number with time. Clinically, they appeared as numerous brown macules, ranging in size from 1 to 5 mm in diameter, in a peppered distribution over an area extending bilaterally on the neck, chin, and cheeks. On the trunk the lesions were localized to the left shoulder and breast, involving the axilla and upper part of the abdomen down to the umbilicus. Four café au lait macules ranging in diameter from 10 to 15 mm were present, with no evidence of neurofibromas. Histopathology of a macule showed the features of lentigo; in addition, groupings of melanocytes were observed at the dermoepidermal junction. The differential diagnosis of AL includes speckled lentiginous nevus and segmental neurofibromatosis.
簇状雀斑样痣（AL）的特征是大量雀斑局限于身体的一个节段，在中线处有明显分界。迄今为止，文献中仅报道了13例。我们报告一名30岁患有多灶性AL的女性。皮肤损害最初在5岁时出现，并且随着时间推移数量逐渐增加。临床上，它们表现为大量褐色斑疹，直径从1至5毫米不等，呈点状分布于双侧颈部、下巴和脸颊的区域。在躯干上，损害局限于左肩和乳房，累及腋窝及腹部上半部分直至脐部。有4个直径为10至15毫米的咖啡牛奶斑，无神经纤维瘤证据。一个斑疹的组织病理学显示为雀斑样痣的特征；此外，在真皮表皮交界处观察到黑素细胞聚集。AL的鉴别诊断包括斑点状雀斑样痣和节段性神经纤维瘤病。
