Maggi E, Perani G, Falaschi F, Frattoni A, Martignoni A, Finardi G, Stefano P L, Simeone F, Paolini G, DeVecchi E
Département de Médecine interne et Thérapie médicale, Université de Pavie, Pavia, Italy.
Presse Med. 1994;23(25):1158-62.
Evidence has been obtained indicating that oxidation of low-density lipoproteins (LDL) plays a relevant role in the pathogenesis of atherosclerosis and it has been proposed that, due to the antigenic properties of oxidized LDL, the anti-oxLDL antibody titre could represent a useful index of in vivo LDL oxidation.
Sixty-nine control subjects and 64 patients scheduled for selective coronary revascularization were investigated before surgery.
The coronary disease patients had a higher level of total plasma cholesterol, LDL cholesterol and triglycerides, and a lower level of HDL cholesterol. Plasma anti-oxLDL antibody titre was measured as the ratio of antibody binding to CuSO4-oxidised LDL versus native LDL. The antibody ratio was higher in coronary patients as compared with control subjects (1.56 +/- 0.5 vs 1.0 +/- 0.3, p < 0.01). A ratio higher than 1.34 (mean of controls +/- one standard deviation) was present in 60% of the coronary patients. Subclass analysis indicated that the presence of diabetes mellitus and hypercholesterolaemia (but not of hypertension, generalized arteriosclerosis, myocardial infarction and cigarette smoking) increased the anti-oxLDL antibody ratio to 1.72 +/- 0.4 and 1.68 +/- 0.3 respectively.
The results obtained indicate that a) a high titre of anti-oxLDL antibodies is present in plasma of patients with coronary atherosclerosis, b) in these patients LDL oxidation takes place in vivo and probably plays a critical role in the development and progression of atherosclerosis.
已获得证据表明低密度脂蛋白（LDL）氧化在动脉粥样硬化发病机制中起相关作用，并且有人提出，由于氧化LDL的抗原特性，抗氧化型LDL（oxLDL）抗体滴度可能代表体内LDL氧化的一个有用指标。
对69名对照受试者和64名计划进行选择性冠状动脉血运重建的患者在手术前进行了调查。
冠心病患者的血浆总胆固醇、LDL胆固醇和甘油三酯水平较高，而HDL胆固醇水平较低。血浆抗oxLDL抗体滴度通过抗体与硫酸铜氧化的LDL结合量与天然LDL结合量的比值来测定。与对照受试者相比，冠心病患者的抗体比值更高（1.56±0.5对1.0±0.3，p<0.01）。60%的冠心病患者的比值高于1.34（对照组平均值±一个标准差）。亚组分析表明，糖尿病和高胆固醇血症（而非高血压、全身性动脉硬化、心肌梗死和吸烟）的存在分别使抗oxLDL抗体比值增加至1.72±0.4和1.68±0.3。
获得的结果表明：a）冠状动脉粥样硬化患者血浆中存在高滴度的抗oxLDL抗体；b）在这些患者中，LDL氧化在体内发生，并且可能在动脉粥样硬化的发生和发展中起关键作用。
