Shikaeva F V, Efimenko N F
Probl Endokrinol (Mosk). 1994 Jul-Aug;40(4):33-5.
Examinations of 33 patients with the polycystic ovaries syndrome with measurements of monoamines, ovarian and gonadotropic hormones, and prolactin revealed disordered monoaminergic regulation in all the patients, manifesting by reduced dopamine level in normoprolactinemia and its reduction parallelled by increase of serotonin level in hyperprolactinemia. Disturbances in monoaminergic regulation result in increased level of LH and reduction of FSH levels in all the patients, as well as different prolactin levels. Hyperandrogenism in patients with the polycystic ovaries syndrome and normoprolactinemia is determined by a unidirectional increase of testosterone and androstenedione, whereas in hyperprolactinemia a sharp increase of testosterone content occurs in parallel with decrease of androstenedione level. Normal total estradiol level was associated in all the examinees with manifest relative hypoestrogenism. The detected disorders in hormonal-mediator relationships in patients with the polycystic ovaries syndrome give us new information on the pathogenesis of this condition, which may be important for its diagnosis and treatment.
对33例多囊卵巢综合征患者进行了单胺、卵巢和促性腺激素以及催乳素的检测，结果显示所有患者均存在单胺能调节紊乱，表现为正常催乳素血症时多巴胺水平降低，高催乳素血症时多巴胺水平降低同时血清素水平升高。单胺能调节紊乱导致所有患者LH水平升高、FSH水平降低以及不同的催乳素水平。多囊卵巢综合征患者正常催乳素血症时的高雄激素血症由睾酮和雄烯二酮单向升高决定，而高催乳素血症时睾酮含量急剧升高同时雄烯二酮水平降低。所有受检者中总雌二醇水平正常与明显的相对雌激素缺乏相关。多囊卵巢综合征患者激素 - 介质关系中检测到的紊乱为该疾病的发病机制提供了新信息，这可能对其诊断和治疗具有重要意义。
