转录因子MyoD家族的分子进化
Molecular evolution of the MyoD family of transcription factors.
作者信息
Atchley W R, Fitch W M, Bronner-Fraser M
机构信息
Department of Genetics, North Carolina State University, Raleigh 27695-7614.
出版信息
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11522-6. doi: 10.1073/pnas.91.24.11522.
Abstract
Myogenesis in skeletal muscle is a cascade of developmental events whose initiation involves the MyoD family of transcription factors. Evolutionary analyses of amino acid sequences of this family of transcriptional activators suggest that the vertebrate genes MyoD1, myf-5, Myog (myogenin), and myf-6 were derived by gene duplications from a single ancestral gene. A common genetic origin predicts some functional redundancy between MyoD1 and myf-5 and between Myog and myf-6. Experimental studies have suggested that these pairs of genes can substitute for each other during myogenesis. Separate analyses of the conserved basic helix-loop-helix and nonconserved flanking elements yield similar branching sequences but show evolutionary change in the basic helix-loop-helix region has occurred at a much slower rate.
摘要
骨骼肌中的肌生成是一系列发育事件，其起始涉及转录因子的MyoD家族。对该转录激活因子家族氨基酸序列的进化分析表明，脊椎动物基因MyoD1、myf-5、Myog（肌细胞生成素）和myf-6是通过基因复制从单个祖先基因衍生而来的。共同的遗传起源预示着MyoD1和myf-5之间以及Myog和myf-6之间存在一些功能冗余。实验研究表明，这几对基因在肌生成过程中可以相互替代。对保守的碱性螺旋-环-螺旋和非保守侧翼元件的单独分析产生了相似的分支序列，但表明碱性螺旋-环-螺旋区域的进化变化发生的速度要慢得多。
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本文引用的文献
1
Myogenin gene disruption results in perinatal lethality because of severe muscle defect.肌细胞生成素基因的破坏由于严重的肌肉缺陷导致围产期致死。
Nature. 1993 Aug 5;364(6437):532-5. doi: 10.1038/364532a0.
2
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene.肌细胞生成素基因靶向突变小鼠的肌肉缺陷与新生儿死亡
Nature. 1993 Aug 5;364(6437):501-6. doi: 10.1038/364501a0.
3
Helix-loop-helix proteins as regulators of muscle-specific transcription.作为肌肉特异性转录调节因子的螺旋-环-螺旋蛋白
J Biol Chem. 1993 Jan 15;268(2):755-8.
4
Regulation of muscle transcription by the MyoD family. The heart of the matter.MyoD家族对肌肉转录的调控。问题的核心。
Circ Res. 1993 Jan;72(1):1-6. doi: 10.1161/01.res.72.1.1.
5
Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice.来自相连的Myf-5和MRF4基因的分离序列在转基因小鼠中驱动不同模式的肌肉特异性表达。
Development. 1993 May;118(1):61-9. doi: 10.1242/dev.118.1.61.
6
MyoD or Myf-5 is required for the formation of skeletal muscle.成肌细胞决定因子（MyoD）或肌原性因子-5（Myf-5）是骨骼肌形成所必需的。
Cell. 1993 Dec 31;75(7):1351-9. doi: 10.1016/0092-8674(93)90621-v.
7
HLH proteins, fly neurogenesis, and vertebrate myogenesis.HLH蛋白、果蝇神经发生与脊椎动物肌发生。
Cell. 1993 Dec 3;75(5):827-30. doi: 10.1016/0092-8674(93)90525-u.
8
The neighbor-joining method: a new method for reconstructing phylogenetic trees.邻接法：一种重建系统发育树的新方法。
Mol Biol Evol. 1987 Jul;4(4):406-25. doi: 10.1093/oxfordjournals.molbev.a040454.
9
CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.CLUSTAL：一个用于在微型计算机上进行多序列比对的程序包。
Gene. 1988 Dec 15;73(1):237-44. doi: 10.1016/0378-1119(88)90330-7.
10
A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.一种与MyoD1相关但又不同的新型人类肌肉因子可诱导10T1/2成纤维细胞发生肌源性转化。
EMBO J. 1989 Mar;8(3):701-9. doi: 10.1002/j.1460-2075.1989.tb03429.x.
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