口服多柔比星对变应原诱导的支气管痉挛影响的进一步研究。

Further studies on the effect of oral doxantrazole on allergen-induced bronchospasm.

作者信息

Pauwels R, Lamont H, van der Straeten M

出版信息

Acta Allergol. 1976 Dec;31(6):471-7. doi: 10.1111/j.1398-9995.1976.tb01497.x.

DOI:10.1111/j.1398-9995.1976.tb01497.x

Abstract

The protective effect of oral doxantrazole on allergen-induced bronchoconstriction in man has been tested in two different treatment schedules. A single administration of 200 mg or 400 mg doxantrazole did not result in significant protection for a group of 10 patients. Only two patients after 200 mg, and three patients after 400 mg received meaningful protection. A 14-day period of treatment with three times 400 mg doxantrazole per day had no significant different effect compared with placebo treatment on allergen-induced broncho-constriction.

摘要

已在两种不同治疗方案中测试了口服多沙唑嗪对人类变应原诱导支气管收缩的保护作用。对一组10名患者单次给予200 mg或400 mg多沙唑嗪未产生显著保护作用。200 mg后只有两名患者，400 mg后只有三名患者获得了有效保护。每天三次400 mg多沙唑嗪治疗14天，与安慰剂治疗相比，对变应原诱导支气管收缩的影响无显著差异。