Constructing a physical map around a constitutional t(1;13)(q22;q12) breakpoint in a patient with a ganglioneuroblastoma.

We have constructed a detailed physical map around the 13q12 region containing the constitutional chromosome translocation breakpoint from a patient with ganglioneuroblastoma. Further analysis will allow us to determine whether a gene vital for the development of sympathetic neural tissue has been disrupted by this genetic change.