内皮素C末端六肽增加小鼠的梳理行为。

Endothelin-C-terminal hexapeptide increases grooming in mice.

作者信息

Scherrer J, Morley J E, Flood J F

机构信息

Geriatric Research, Education and Clinical Center, St. Louis VA Medical Center, MO 63106.

出版信息

Pharmacol Biochem Behav. 1994 Aug;48(4):1031-5. doi: 10.1016/0091-3057(94)90216-x.

DOI:10.1016/0091-3057(94)90216-x

PMID:7972281

Abstract

Grooming behavior has been considered a response to stress, and a number of stress-related peptides have been demonstrated to modulate grooming behavior. In the experiments reported here, endothelin-C-terminal hexapeptide containing amino acid residues 16-21, ET[16-21], increased grooming with a maximum effect at 0.75 microgram. ET[16-21] did not significantly alter eating or locomotor behavior. Both alpha-helical CRF (10 micrograms) and neuropeptide Y (1 microgram) inhibited the grooming produced by ET[16-21].

摘要

修饰行为被认为是对压力的一种反应，并且已经证明许多与压力相关的肽可以调节修饰行为。在本文报道的实验中，含有氨基酸残基16 - 21的内皮素C末端六肽ET[16 - 21]，以0.75微克时效果最佳，可增加修饰行为。ET[16 - 21]并未显著改变进食或运动行为。α - 螺旋促肾上腺皮质激素释放因子（10微克）和神经肽Y（1微克）均抑制ET[16 - 21]所产生的修饰行为。