Fahlke C, Hård E, Thomasson R, Engel J A, Hansen S
Department of Psychology, University of Göteborg, Sweden.
Pharmacol Biochem Behav. 1994 Aug;48(4):977-81. doi: 10.1016/0091-3057(94)90208-9.
The fluid intake of male Wistar rats with simultaneous access to water and 6% ethanol was determined between 0900 and 1500 h. In high-preferring males (normally covering > 60% of their daily fluid consumption in the form of ethanol), two injections with the corticosterone synthesis inhibitor metyrapone (50 mg/kg) at 0900 h and 1200 h for 4 consecutive days significantly reduced ethanol preference such that they preferred water over alcohol. Treatment with corticosterone (0.6 mg/kg) 2 h before each metyrapone injection partially cancelled this effect of the synthesis inhibitor. By contrast, there was no significant effect of metyrapone treatment on the drinking of ethanol in low-preferring rats (normally covering < 30% of their daily fluid consumption in the form of ethanol). These results suggest that the adrenal secretion of corticosterone directly or indirectly modulates the intake of alcohol in high-preferring rats.
在上午9点至下午3点之间测定了同时能获取水和6%乙醇的雄性Wistar大鼠的液体摄入量。在高偏好雄性大鼠（通常以乙醇形式摄入的液体占其每日液体摄入量的60%以上）中，连续4天在上午9点和中午12点注射两次皮质酮合成抑制剂美替拉酮（50毫克/千克），显著降低了乙醇偏好，使其更偏好水而非酒精。在每次美替拉酮注射前2小时用皮质酮（0.6毫克/千克）处理，部分抵消了合成抑制剂的这种作用。相比之下，美替拉酮处理对低偏好大鼠（通常以乙醇形式摄入的液体占其每日液体摄入量的30%以下）的乙醇饮用没有显著影响。这些结果表明，肾上腺分泌的皮质酮直接或间接调节高偏好大鼠的酒精摄入量。
