Didry N, Dubreuil L, Pinkas M
Laboratoire de Pharmacognosie, Faculté des Sciences pharmaceutiques et biologiques, Lille, France.
Pharmazie. 1994 Sep;49(9):681-3.
The activity of anthraquinonic compounds and naphthoquinones was tested by micromethods against oral bacteria. The more significant results were obtained with naphthoquinones. Plumbagin, juglone and lawsone possess a wide spectrum of activity. The lowest MIC values were observed with plumbagin and the combination of juglone and lawsone results in a synergism against cariogenic bacteria. Among the eight anthraquinonic compounds investigated only rhein showed significant antimicrobial properties. Results obtained could suggest the use of rhein and plumbagin alone or juglone and lawsone combined for treatment of oral infectious diseases.
采用微量法检测了蒽醌类化合物和萘醌类化合物对口腔细菌的活性。萘醌类化合物取得了更显著的结果。白花丹素、胡桃醌和紫铆因具有广泛的活性。白花丹素的最低抑菌浓度值最低，胡桃醌和紫铆因组合对致龋菌具有协同作用。在所研究的八种蒽醌类化合物中，只有大黄酸表现出显著的抗菌特性。所得结果表明，大黄酸和白花丹素单独使用或胡桃醌和紫铆因联合使用可用于治疗口腔感染性疾病。
