VanderWeele D A
Department of Psychology, Occidental College, Los Angeles, CA 90041.
Physiol Behav. 1994 Sep;56(3):619-22. doi: 10.1016/0031-9384(94)90310-7.
The present study assessed meal-contingent insulin effects on spontaneous meal patterns. Rats, trained to lever press for daily food requirements, showed stable meal patterns and were then implanted with hepatic-portal catheters. Once again stable in ingestion, animals received either physiological saline or vehicle plus 1 or 2 mU of regular, short-acting insulin beginning at 10 pellets into each initiated meal (which was the chosen minimum meal size definition). All meals during that day were then infused with the same solution and comparisons were made within animals (across days) only. Insulin reduced the size of spontaneous meals at both 1 mU (p < .01) and 2 mU doses (p < .001). No other meal parameters were significantly affected. In a complementary study, rats trained to lever press showed increases in meal size when "recovering from" a diazeoxide-adulterated diet (diazeoxide has been shown to limit insulin release). Thus, when insulin is increased during spontaneously taken meals, those meals are reduced in size and drugs which block insulin release, increase the size of meals; we assert insulin is a prandial satiety hormone which likely reduced feeding by increasing glucose uptake into peripheral tissue.
本研究评估了随餐给予胰岛素对自发进食模式的影响。大鼠经过训练通过按压杠杆获取每日所需食物，表现出稳定的进食模式，随后植入肝门静脉导管。在进食再次稳定后，动物从每餐摄入10颗食丸开始（这是选定的最小餐量定义），接受生理盐水或赋形剂加1或2 mU的正规短效胰岛素。当天所有餐次均输注相同溶液，仅在动物体内（跨日）进行比较。胰岛素在1 mU（p <.01）和2 mU剂量（p <.001）时均减小了自发餐量的大小。没有其他餐食参数受到显著影响。在一项补充研究中，经过训练按压杠杆的大鼠在“从”掺有二氮嗪的饮食中“恢复”时，餐量增加（已证明二氮嗪会限制胰岛素释放）。因此，当自发进食期间胰岛素增加时，餐量会减小，而阻断胰岛素释放的药物会增加餐量；我们认为胰岛素是一种餐时饱腹感激素，可能通过增加外周组织对葡萄糖的摄取来减少进食。
